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The homologous DDRs are composed of an N
2020-09-21
The homologous DDRs are composed of an N-terminal discoidin homology domain, followed by a sequence of ∼220 amino acids unique to the DDRs, a transmembrane domain, a large juxtamembrane domain, and a conserved cytoplasmic tyrosine kinase domain. In a previous study, we demonstrated that DDR activati
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In the context of food allergy
2020-09-21
In the context of food allergy it is hypothesized that intestinal barrier dysfunction might contribute to both antigen sensitization and the IgE/mast cell mediated effector phase of allergic disease, however no concluding data has been published to date [5]. An understanding of the mechanism of prim
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In these studies the inflammatory cytokine IL
2020-09-21
In these studies, the inflammatory cytokine IL-8 was demonstrated as one of the responsible molecules induced by CysLTs via activating CysLT2 receptors. IL-8 is synthesized in and released from mononuclear cells, macrophages, fibroblasts and airway epithelial cells, and it promotes inflammation as a
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As described above we designed
2020-09-21
As described above, we designed and synthesized a new 1,4-di-substituted isoquinoline lead compound, and was identified as a ligand with moderate potency for the CRTH2 receptor. We initially we examined the effects of the steric factor of R group on the CRTH2 binding potency (). When the methyl gro
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The use of inhibitors clearly has its caveats
2020-09-19
The use of inhibitors clearly has its caveats and the field should come to a consensus on etomoxir concentration to maximally block LC-FAO while minimalizing off-target effects. The current papers convincingly show that 200 μM is too high, but it should be noted that 3 μM does not fully suppress LC-
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Conclusions br Acknowledgements The study was supported by a
2020-09-19
Conclusions Acknowledgements The study was supported by a grant from the Argentine National Agency for the Promotion of Science and Technology (ANPCyT) (PICT 2012-2649). N.R.S., H.H.O., G.J.H. and F.R. are research career members and N.C.G., E.A., E. H., F.M.R., are fellows of the National Scien
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br System description and data collection Fig shows the
2020-09-19
System description and data collection Fig. 1 shows the arrangement of the system studied. It provided cooling topoisomerase to maintain thermal conditions in an institutional building. The locations of the measured variables (, and ) relating to temperature and flow rate are indicated in Fig. 1
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Several TERRA binding proteins have also been discovered
2020-09-19
Several TERRA-binding proteins have also been discovered, especially telomeric duplex DNA binding proteins TRF1 and TRF2, pointing to a significant role of TERRA in more general chromosome biology [14], [20], [21]. TRF2 is a key component of Shelterin that protect chromosome termini [22]. Telomeres
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Gastrointestinal tone can be effectively modulated
2020-09-19
Gastrointestinal tone can be effectively modulated by cholinesterase inhibitors. As parasympathetic fibers release Rifabutin synthesis to contract the circular and longitudinal intestinal muscles, AChE inhibition can facilitate those actions. Postoperative ileus (delayed gastric emptying after surg
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Introduction Hepatocarcinoma is a common and aggressive form
2020-09-19
Introduction Hepatocarcinoma is a common and aggressive form of cancer (Trad et al., 2017). Due to a high rate of postoperative recurrence and metastasis, the prognosis for HCC remains dismal (Wang et al., 2017a, 2017b). Subclinical metastasis is the major cause responsible for tumor recurrence and
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In conclusion the results obtained in this study and those
2020-09-19
In conclusion, the results obtained in this study and those recently reported by our group (Abdel-Samad et al., 2012) clearly indicate that a dialogue indeed exists between the systems of NPY and ET-1 at the level of human endocardial endothelial cells, since these cells, whether isolated from the r
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Damage of PE HD due to both mechanisms
2020-09-19
Damage of PE-HD due to both mechanisms is usually considered to emerge from a local stress concentration in the material, leading to the initiation of a crack, which subsequently propagates further through the material, and finally leads to macroscopic failure. In this process, crack growth occurs o
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River sand was graded in accordance with ASTM
2020-09-19
River sand was graded in accordance with ASTM C778 [47] (see Table 2). The graded sand had a water CCT241533 hydrochloride synthesis of 1.00%, fineness modulus of 3.49 and specific gravity of 2350kg/m3. A polycarboxylate based superplasticizer called ZP with pH of 7±1 and specific gravity of 1.1±0
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br The orphan estrogen related receptor exists as three subt
2020-09-19
The orphan estrogen-related receptor exists as three subtypes (ERRα, ERRβ, and ERRγ) in the human genome. ERRα is expressed in metabolically active tissues such as muscle and adipose. ERRγ is expressed in the spinal cord and CNS. ERRβ appears to play a role in development, as postnatal expression
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br Acknowledgements br Introduction Endothelial cells consti
2020-09-19
Acknowledgements Introduction Endothelial Magnolol synthesis constitute a unique source of humoral factors that may regulate the functions of other cell types via paracrine or endocrine pathways [1]. Among the many molecules originated from the endothelium, nitric oxide (NO) plays versatile r
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