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br Abbreviations br Introduction br Collagen induced DDR act
2021-06-04
Abbreviations Introduction Collagen-induced DDR activation A key feature of DDRs is their ability to bind both fibrillar and non-fibrillar collagens (Shrivastava et al., 1997, Vogel et al., 1997). DDR1 and DDR2 recognize the GVMGVO (O, hydroxyproline) motif within fibrillar collagens I–III
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What are the molecular signals that guide Tfh
2021-06-04
What are the molecular signals that guide Tfh cells as they navigate around the lymph node in the course of the immune response? It was recently reported that Tfh cells inside GCs have high expression of SIPR2, which acts to repel them from the S1P-rich lymph in the SCS and promote their retention i
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br Acknowledgment This work was
2021-06-04
Acknowledgment This work was supported by the Estonian Science Foundation (Grant ETF8862). Introduction In higher eukaryotes ionizing-radiation (IR) induced DNA double-strand breaks (DSB) are primarily repaired by the non-homologous end joining (NHEJ) pathway [1]. Ku, a heterodimeric protein
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An important strength of our study is the use
2021-06-04
An important strength of our study is the use of an elastic net regression model to select the variable and construct the model, which performed ideally in terms of both predictive accuracy and sparsity for the high-dimensional datasets [16]. As a result, the apparent predictive effect of multiple c
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Ebastine The body wall intestine seminal receptacle and semi
2021-06-03
The body wall, intestine, seminal receptacle and seminal vesicle in the adult worms were also isolated and homogenized to make microsomal fractions to investigate the relative expression of CYP1A2, CYP2E1 and CYP3A4 in these different organs. In order to get sufficient mass, about 20 individual adul
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In this study a GMI of was
2021-06-03
In this study, a GMI of 1.0 was associated with high sensitivity above 90%, specificity below 30% and higher negative predictive value. However, this cut-off couldn't have been optimal because of the lower level of Youden J Index which was 50% of patients with culture positive sputum had a GMI >6.0.
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More recently it was discovered
2021-06-03
More recently, it was discovered that BChE hydrolyzes the neuropeptide gut hormone, ghrelin [25], [26], [27], [28]. Nonetheless, because the enzyme reaction is very slow, those who first reported this finding were initially reluctant to attribute a real physiological role for that phenomenon. Our ow
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br Acknowledgements This work was supported by grants from N
2021-06-03
Acknowledgements This work was supported by grants from National Natural Science Foundation of China (31772196 and 31301693), the Chinese Ministry of Agriculture (the 948 project no. 2014-S10). Rothamsted Research also receives grant-aided support from the UK Biotechnology and Biological Sciences
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Iberin synthesis Two isoforms of intracellular ER ER
2021-06-03
Two isoforms of intracellular ER, ERα, and ERβ, after binding to estrogens and translocate to the nucleus, activate some transcription factors and signaling pathways. The deregulation of estrogenic pathways can elevate transcriptional activity contributed to the development of cancer. Expression of
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In the present study we
2021-06-03
In the present study we examined whether the gene for estrogen receptor alpha, Esr1, plays a role in the expression of maternal memory in female rats. The approach utilized a newly developed rat Esr1 knockout (KO) rat model (Rumi et al., 2014) to evaluate whether deletion of the Esr1 IFN-alpha 1, hu
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br Conflict of interest br Supplementary
2021-06-03
Conflict of interest Supplementary methods and materials Acknowledgments This work was supported by an Early Career Researcher grant awarded by the Institute of Health and Biomedical Innovation to IMW and Queensland University of Technology, and grants awarded to SS by the Prostate Cancer F
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Our previous high throughput screening HTS campaign using
2021-06-03
Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based p53 tumor suppressor assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimizations [20], [21]
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In the present study we first examined the in vivo
2021-06-03
In the present study, we first examined the in vivo and ex vivo effects of androgens on ep1 MI-773 australia in the olfactory rosette of male B. sinensis. Thereafter, we cloned two different B.sinensis ar cDNAs and investigated their roles in the effects of 11-KT on ep1 expression. Material and
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If the effects described here
2021-06-03
If the effects described here are present in catalysis, their empirical confirmation poses many challenges. Cat state correlations are fragile outside an environment especially suited for their preservation. As present day observational techniques whether in vivo or in vitro were not designed bearin
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OxLDL down regulates eNOS and up
2021-06-03
OxLDL down-regulates eNOS and up-regulates iNOS, thereby augmenting the formation of NO and protein S-nitrosylation in human endothelial Chlorhexidine digluconate [26]. Importantly, iNOS-mediated S-nitrosylation plays an increasingly significant role in cardiovascular diseases [34]. For example, iN
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