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br Acknowledgments The research in this study was supported
2021-06-10
Acknowledgments The research in this study was supported by grants from CMHS, UAE University and Qatar University. The authors gratefully acknowledge Dr. R Lukas (Barrow Neurological Institute, Phoenix, AZ, USA) for SH-EP1 MG 262 stably expressing the human α7 nACh and human α4β2 nACh receptor an
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br Methods br Results br Discussion I R induces
2021-06-10
Methods Results Discussion I/R induces oxidative stress and increases the intracellular levels of ROS, resulting in tissue damage [31]. ROS is generated by mitochondrial electron transport chain, nicotinamide T16Ainh - A01 dinucleotide phosphate (NADPH) oxidase complex, xanthine oxidase an
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br Protein protein interactions of LEI L
2021-06-10
Protein-protein interactions of LEI/L-DNase II and the control of cell death Evolutionary tips The serpin inhibitory mechanism is extremely well adapted to evolutionary changes because a single amino GDC-0623 substitution in the RSL can led to the inhibition of a totally different protease. W
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br Conclusions br Introduction The terms
2021-06-10
Conclusions Introduction The terms endocrine active and endocrine disruptive have been used to describe an ever-expanding list of naturally-occurring and synthetic compounds that interact with mammalian hormonal systems, and in particular, the reproductive system. These compounds have been ass
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Diabetic retinopathy is a chronic inflammatory disease Local
2021-06-09
Diabetic retinopathy is a chronic inflammatory disease. Local inflammation plays a pivotal role in the pathological development and progression of this disease [24]. In addition to TNF-α, several other cytokines, chemokines, and other factors such as IL-1β, IL-6, and C-reactive protein have been ind
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We have previously reported DAPK inhibitors discovered throu
2021-06-09
We have previously reported DAPK inhibitors discovered through our structure-based virtual screening (SBVS) research program. In this paper, we describe the general protocol of our in silico approach, and the strategy used to develop hit compounds. In addition, the studies conducted on the structure
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Functionally all members of the IL family have been
2021-06-09
Functionally, all members of the IL-12 family have been annotated along major inflammatory signaling axes but their roles have often weighed on opposing sides of the immunological balance. For instance, IL-12 and IL-23 are classified as pro-inflammatory cytokines [10] as opposed to the rather protec
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Culture conditions particularly temperature which affect
2021-06-09
Culture conditions (particularly temperature), which affect the pathogenicity of Y. enterocolitica (Bottone, 1997), may also impact its inhibitory properties against cysteine proteases. However, culturing the bacterial strains at 37 instead of 28 °C did not alter remarkably the inhibitory potential
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br Methods br Results Our study focused on consecutive
2021-06-09
Methods Results Our study focused on consecutive postural adjustments (CPAs) between IS and BS (the shaded areas on Fig. 2); that is to say, the Rx kinetics that occur after the end of an upper limb movement. It was dedicated to examining the main features of CPAs and the influence of movement
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In conclusion BmSpry was targeted by three
2021-06-09
In conclusion, BmSpry was targeted by three viruses to regulate the ERK pathway and thus ensure viral reproduction in the silkworm. This is the first report regarding a general mechanism of host regulation by multiple silkworm viruses, and this can pave the way for future virus control in other inse
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It is well known that
2021-06-09
It is well known that acrolein, a metabolite of cyclophosphamide, is responsible for the cyclophosphamide-induced cystitis, and that acrolein is capable of activating TRPA1 channels expressed in the capsaicin-sensitive primary afferents [2], [11]. In this context, it is likely that the early phase o
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Importantly MPO is not only a marker
2021-06-09
Importantly, MPO is not only a marker of cardiovascular disease but also emerges as a critical mediator of vascular inflammatory disease: Liberated MPO binds to the endothelium in a leukocyte-independent manner, is subsequently taken up by the endothelium and transcytoses and accumulates in the sube
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Overall the evidence and the results from
2021-06-09
Overall, the evidence and the results from in vivo studies clearly indicate that cyclosporine biotransformation can be induced by dasatinib co-administration through induction of CYP3A expression. However, further studies are needed to explore the role of P-gp modulation in DDIs. Conclusion In v
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br Introduction Concern has been raised over free
2021-06-08
Introduction Concern has been raised over free estrogens (estrone [E1], 17ß-estradiol [E2] and 17α-ethynylestradiol [EE2] particularly) in the past decade due to their endocrine disrupting effects on environmental biota [1], [2]. Estrogens are excreted by vertebrates primarily as sulfate or glucu
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Elevation of plasma glucocorticoids as well
2021-06-08
Elevation of plasma glucocorticoids as well as a sympathetic activation are highly adaptive mechanisms allowing the individual to cope in various situations [39]. Novelty-induced increase in locomotor activity, characterizing the bold fish herein, accompanied by elevated glucocorticoids is a well-es
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