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DNA bound Ku proteins recruit DNA PKcs and thereby transloca
2021-06-15
DNA-bound Ku proteins recruit DNA-PKcs; and thereby translocate into the duplex by one helical turn, leaving DNA-PKcs near the DNA terminus to assist in tethering the broken ends together [25]. In addition to keeping the DSBs in close proximity, DNA-PKcs may prevent exonucleolytic degradation of the
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The occurrence of three Ag NORs
2021-06-15
The occurrence of three Ag-NORs per metaphase and/or a maximum of three nucleoli per nucleus in most of the varieties may be explained by chromosomal rearrangements or unequal crossing-over events that induce the deletion of the fourth active rDNA loci. Also, the chromosome pair that showed less int
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Tamoxifen is included in the
2021-06-15
Tamoxifen is included in the treatment protocol of ER+ breast carcinoma patients routinely. Although tamoxifen improves patients' survival, unfortunately a large number of ER+ patients don't response to tamoxifen treatment (Yager and Davidson, 2006). Detection of molecular markers which could take a
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Ingested folate needs to be chemically modified in order to
2021-06-15
Ingested folate needs to be chemically modified in order to become a one carbon donor for cell metabolism. Firstly, folate turns to dihydrofolic alk pathway (DHF), it is then converted into tetrahydrofolate (THF) by the dihydrofolate reductase enzyme (DHFR) and finally converted into N5, N10-methyl
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Increasing evidence suggests that normal vaginal delivery
2021-06-15
Increasing evidence suggests that normal vaginal delivery is a natural inflammatory process which results in increased levels of cytokines like Interleukin-6 (IL-6), Interleukin-8 (IL-8) in maternal and cord blood plasma [10]. Increased levels IL-6 and IL-8 have been reported in the amniotic fluid o
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br Conclusion CSF R may contribute to limitation of targeted
2021-06-15
Conclusion CSF-1R may contribute to limitation of targeted therapies by providing EGFR-bypassing signals that support proliferation. Multi-kinase inhibitors such as cabozantinib are available, and agents targeting CSF-1R are in clinical trials, however, at present, as inhibitors of tumor-associat
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In summary our data demonstrated a biological function
2021-06-11
In summary, our data demonstrated a biological function of cpt1a gene from large yellow croaker. In particular, we indicated the effects of fasting on free carnitine status, CPT1 kinetics, and cpt1a mRNA expression in liver of large yellow croaker. During short-term fasting, the fish liver may have
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MDL800 The anticholinesterase activities of all subfractions
2021-06-11
The anticholinesterase activities of all subfractions derived from EtOAc extract were detected and summarized in . Fraction 5 and its resulting subfractions (5B, 5C, 5D, 5C3, 5C4, 5D3, and 5D4) were found to show attractive activities. Subsequently, ten compounds (–) were obtained from these active
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Analysis of DNA fragmentation We followed a
2021-06-11
Analysis of DNA fragmentation. We followed a modified Hirt extraction procedure for analysis of DNA fragmentation. Cells were suspended in TNE buffer (1M NaCl, 20mM Tris–HCl, pH 7.4, 2mM EDTA, and 0.6% SDS) at a density of 106 cells/ml and incubated overnight on ice. The next day, cellular debris wa
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The same reservoir of genes is involved in fusions in
2021-06-11
The same reservoir of nitric oxide synthase inhibitor is involved in fusions in all types of cancers, which predominantly encode kinases and transcriptional factors [102]. This makes fusion genes potential pan-cancer targets, and renders tumor categorization based on genetic profiling therapeutical
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The underlying assumption of consolidation re consolidation
2021-06-11
The underlying assumption of consolidation/re-consolidation is that the 7ACC1 mg activity initiated during the acquisition trial/re-consolidation trial continues to persist briefly after completion of the trial and it is during this post-trial period that immediate post-trial treatments can influen
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br No Evidence for Further ET Receptor Subtypes
2021-06-11
No Evidence for Further ET-Receptor Subtypes Further receptor subclassifications have been proposed including suggestions that ETB could be subdivided into ETB1, present on endothelial cells, and ETB2 on smooth muscle cells, but there currently is no evidence that the receptors expressed by these
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br Materials and methods br
2021-06-11
Materials and methods Results Discussion In this study, we employed a liquid chromatography mass spectrometry (LC–MS)-based metabolomic approach to profile GEF metabolism and bioactivation in human and mouse liver microsomes. Metabolomic approaches rendered us readily screen out the GEF-rel
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br Genes involved in oxysterol metabolism The
2021-06-11
Genes involved in oxysterol metabolism The main enzymes that participate in the metabolism of oxysterols generally belong into one of two groups: transferases or oxidoreductases [22]. The following chapter describes those genes of oxysterol metabolism whose polymorphisms have been associated with
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Acridine Orange hydrochloride sale In addition to grouping c
2021-06-11
In addition to grouping cases of B-ALL by cell of origin, these lymphomas can also be subcharacterized by genetic rearrangements. Fusion of the purinergic receptor P2RY8 promoter to the CRLF2 (cytokine receptor like factor 2) gene frequently occurs in B-ALL but reports of the functional consequences
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