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br Materials and methods br Results br Discussion Plant
2021-06-19
Materials and methods Results Discussion Plant U-box E3 Ub ligases regulate diverse plant-specific cellular processes [1], [2], [3], [4]. However, structural and functional relationships between U-box E3s and their E2 partners are largely unknown in higher plants [24], [25]. In this study,
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br Introduction O Methylguanine DNA methyltransferase MGMT
2021-06-19
Introduction O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA-repair enzyme that specifically transfers alkyl adducts from the O6 position of guanine to the cysteine residue (Cys145) in its active site. In cancer cells, this ability of MGMT disrupts the cytotoxic actions of alkylating antic
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The Rev protein is a crucial regulator of
2021-06-19
The Rev1 protein is a crucial regulator of TLS activity because of its structural function [10]; therefore, we focused on Rev1 to investigate how Dot1/Rad53 function impinges on TLS-dependent mutagenic bypass of MMS-induced lesions. In particular, we examined Rev1 localization to chromatin by immuno
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Cultured cells or mouse lung tissues
2021-06-19
Cultured cells or mouse lung tissues were harvested and lysed in Radio-Immunoprecipitation Assay (RIPA) buffer (0.05 mol/l Tris–HCl pH 7.4, 0.15 mol/l NaCl, 0.25% deoxycholic acid, 1% NP-40, 1 mmol/l ethylenediamine tetraacetic Fmoc-L-Arg(Aloc)2-OH australia (EDTA), 1 mmol/l phenylmethylsulfonyl f
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Atipamezole hydrochloride Fig S an adrenoceptor antagonist i
2021-06-19
Atipamezole hydrochloride (Fig. S1), an α2-adrenoceptor antagonist, is commonly used by veterinarians to recover animals from sedation-anesthesia induced by α2-adrenoceptor agonists. Recent studies in animals suggest that atipamezole might have beneficial effects in MOG (35-55) receptor damage repa
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br CDK Regulators as Coactivators of
2021-06-19
CDK Regulators as Coactivators of NF-κB and STAT CDK regulating proteins also have the ability to control the inflammatory response. The p21CIP1 protein binds to and inhibits the activity of cyclin–CDK4/6 and cyclin–CDK1/2 complexes. Consistent with its ability to inhibit CDK activity, deletion o
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br Acknowledgements We thank Jeus Perez Clausell from the De
2021-06-18
Acknowledgements We thank Jeus Perez-Clausell from the Department of Cell Biology, School of Biology, University of Barcelona, Felipe Casanueva's group from the Department of Molecular Endocrinology and Carlos Diéguez's group from the Department of Physiology, School of Medicine, University of Sa
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To date little is known about mode of action or
2021-06-18
To date, little is known about mode of action or the underlying genetic basis of DEET repellency for human-biting ticks. To begin to unveil these mechanisms, we carried out behavioral assays to confirm the effectiveness of DEET as a deterrent for D. variabilis. RNA sequencing was then used to build
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Although it remains an unsettled
2021-06-18
Although it remains an unsettled issue, evidence favors that the endothelin ETA topoisomerase inhibitors may play a more important pathological role. While both endothelin ETA and ETB receptors are found in most tissues, endothelin ETA receptor is the predominant receptor responsible for the vasoco
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ROS generation is crucial for NETs release
2021-06-18
ROS generation is crucial for NETs release upon both physiological or pathogenic stimuli [16,30]. In our study, we further verified this conclusion by demonstrating that SRA stimulation by Poly I enhanced intracellular ROS levels while scavenging of ROS by anti-oxidant agents effectively abolished t
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In the present study we first examined the
2021-06-18
In the present study, we first examined the in vivo and ex vivo effects of androgens on ep1 lxr agonists in the olfactory rosette of male B. sinensis. Thereafter, we cloned two different B.sinensis ar cDNAs and investigated their roles in the effects of 11-KT on ep1 expression. Material and metho
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Regardless of its effect on EBV infection the chemokine syst
2021-06-18
Regardless of its effect on EBV infection, the chemokine system has been found to be regulated in both nasopharyngeal cancer and Hodgkin lymphoma. As such, Hodgkin and Reed–Sternberg (HRS) cells from Hodgkin lymphoma and nasopharyngeal carcinoma cells have been shown to express CXCL8 and CCL17. Furt
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In pregnancy maternal uterine spiral
2021-06-18
In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK Edaravone (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in humans and in m
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Molecular modelling studies were performed on the hDHFR
2021-06-17
Molecular modelling studies were performed on the hDHFR inhibitors identified (1, 11, 13, 14, 16, 25 and 32) to explore the structural basis of the interaction between the mentioned compounds and the human enzyme. The docking studies were performed using the X-ray crystallographic structure of the h
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br Deregulation of CDK Many
2021-06-17
Deregulation of CDK5 Many neurotoxic or stress conditions like ischemic Deazaneplanocin damage, oxidative stress, mitochondrial dysfunctions, excitotoxicity, Aβ exposure lead to disruption of the tight regulation of Cdk5 (De Strooper et al., 2010). Calpain-mediated cleavage of p35 to p25 is acti
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