• About epilepsy no specific seizure type has been identified

  2021-11-04

  

  About epilepsy, no specific seizure type has been identified because GLUT1-DS is associated with a wide range of epilepsies: patients develop seizures in infancy and early childhood, which are, frequently, do not respond to anticonvulsant medication. In infants, seizures are described as brief, subt

• br Conclusion br Ethics statements file br Conflict of inter

  2021-11-04

  

  Conclusion Ethics statements file Conflict of interest Acknowledgements This study was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIP) (Nos. 2011-0030074 and 2018R1D1A3B07050361) and Sookmyung Women’s University Specialization Pro

• The identity of the K transport

  2021-11-04

  

  The identity of the K+ transport pathway activated by NEM remains unclear. The pathway does not require the presence of Gardos channel KCNN4 or K–Cl cotransporters KCC3 and KCC1, but like these pathways is sensitive to the presence of hemoglobin S or other sickling hemoglobins. Although partially se

• br Lung cancer cell lines The greatest expression of

  2021-11-04

  

  Lung cancer cell lines The greatest expression of both human and rodent FFA4 transcript has been shown to be localized to the lung [61], yet the physiological role in this tissue has been understudied, as has its involvement in lung cancers. In 2015, a two-staged genome-wide association study of

• In stark contrast to this study Zhang

  2021-11-04

  

  In stark contrast to this study, Zhang and colleagues demonstrated that FFA4, along with FFA1, play roles in suppressing cell proliferation and promoting apoptosis in CRC fructose 1 6 bisphosphatase treated with omega-3 PUFA [53]. In this study design, in vivo CRC was induced in mice upon treatment

• br General features of FGFRs and

  2021-11-04

  

  General features of FGFRs and inhibitors Conclusion Given the critical role of FGFRs in the progression of tumors, the co-crystal structures of these kinases in complex with inhibitors are determined in order to clarify the mechanism of actions and explore new efficient inhibitors. This manusc

• The ability of GPX and other

  2021-11-04

  

  The ability of GPX4 and other selenoproteins to be selectively induced by ferroptotic stimuli suggests that the stress-induced increase in the transcription of a number of putative, “antioxidant” selenoproteins is an adaptive homeostatic, but insufficient response to prevent cell death in the face o

• The binding of DHAP to aldolase resulted

  2021-11-04

  

  The binding of DHAP to aldolase resulted in a dramatic decrease of aldolase affinity to FBPase – KAapp was reduced more than 100 times. The dependence of the complex activity versus increasing DHAP concentration was biphasic (Fig. 3a). Supposedly, the first phase of the curve represents the state in

• PKI-402 br Introduction Thrombosis is one of the leading cau

  2021-11-04

  

  Introduction Thrombosis is one of the leading causes of deaths in the cardiovascular diseases such as myocardial infarction (MI), unstable PKI-402 and acute coronary syndrome (ACS) in developed countries [1], [2]. It is estimated that venous thromboembolism (VTE) afflicts about 1 million (1–2 pe

• Senger et al performed a

  2021-11-04

  

  Senger et al. performed a retrospective review of 17 patients with ICH on dabigatran or rivaroxaban who received 4F-PCC. Eight patients had a traumatic Biotin-tyramide injury (TBI) and nine patients had a spontaneous ICH. Nine patients had a devastating outcome, including severe neurologic deficits

• Compounds and were evaluated for their pharmacokinetic

  2021-11-04

  

  Compounds and were evaluated for their pharmacokinetic properties in rats and the results are summarized in . Following intravenous (IV) administration, both compounds displayed low clearance (CL), short half-lives (t) and low volumes of distribution (V). When dosed orally as a solution, exposure

• It is important to mention that the IC of cetirizine

  2021-11-04

  

  It is important to mention that the IC50 of cetirizine needed to achieve histamine H2 receptor desensitization was 0.43 µM or 170 ng/ml (Fig. 1B), becoming clinically relevant since pharmacokinetic studies after oral administration of the clinically used dose (10 mg/day) reported a maximal plasma co

• To efficiently develop bioactive ligands even if

  2021-11-04

  

  To efficiently develop bioactive ligands even if the structural information of the target protein is unknown, we have presented a three-dimensional structural diversity-oriented strategy based on structural properties of a chiral cyclopropane. Our strategy has allowed us to design and synthesize a s

• The rationale for developing HDACi as

  2021-11-03

  

  The rationale for developing HDACi as anticancer agents was based on their ability to induce the hyperacetylation of histones and nonhistone proteins, resulting in increased differentiation, apoptosis, and Cyclosporin A arrest of cancer cells 1, 2, 3. HDACi have been used in the treatment of hematol

• Several recent studies have linked clock

  2021-11-03

  

  Several recent studies have linked clock function with the cell cycle and reported that clock components, such as PER1, PER2, BMAL1, and CRY1/2 decrease cell proliferation or improve the action of anti-cancer drugs in different cancer cell lines. Moreover, certain types of human cancer show an alter

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