• br Recent insights into EAAT structure function

  2022-01-15

  

  Recent insights into EAAT structure/function aspects The EAATs are secondary-active transporters coupling the movement of one Glu with the symport of three Na+ and one proton and the counter-transport of one K+ [3, 4]. The transporters are trimeric assemblies of protomers that function independen

• br Acknowledgments This work was supported by a grant

  2022-01-15

  

  Acknowledgments This work was supported by a grant CIHR-NSFC China-Canada Joint Health Research from the National Science Foundation of China (Grant Number 81061120525) and the Canadian Institutes for Health Research (Grant number CCI-109605). The authors thank two anonymous reviewers for helpful

• Tylophora atrofolliculata is a centuries used folk

  2022-01-14

  

  Tylophora atrofolliculata is a centuries-used folk medicine for the treatment of rheumatism in China (Jiangsu New Medical College, 1977). One group of its bioactive components is phenanthroindolizidine alkaloids, which have been demonstrated as lead compounds of anti-tumor agents in our previous stu

• Finally worth of mention are

  2022-01-14

  

  Finally, worth of mention are few papers that report on the discovery of HO-2 selective inhibitors. In 2013, starting from the screening of a BRD-9424 library, the above-mentioned Canadian research group identified Clemizole (Table 6) as a new hit compound for the development of the first series of

• Nitidine chloride Our findings demonstrated that the express

  2022-01-14

  

  Our findings demonstrated that the expression level of full-length α1 sGC protein was higher in the malignant and benign breast tumors than that of normal tissues. Similarly, an increase in the expression of α1 sGC subunit has been detected in glioma cell lines [34]. Higher expressions of sGCα1 and

• br Conclusion Interactions between neurons and astrocytes

  2022-01-14

  

  Conclusion Interactions between neurons and astrocytes depend on the spatial configuration of their contacts. Therefore, changes of astrocyte morphology may impact various physiological mechanisms ranging from glutamate uptake and potassium homeostasis to modulation of synaptic transmission and p

• Dormancy is a physiological state when viable seeds do

  2022-01-14

  

  Dormancy is a physiological state when viable seeds do not germinate. Seed stratification, a commonly used technique, is used for dormancy removal and can be performed in moisture for an experimentally revealed time at warm or cold temperatures. All conditions depends on plant species (Dębska et al.

• Two distinct mechanisms have been described for niacin

  2022-01-14

  

  Two distinct mechanisms have been described for niacin’s macrophage-based actions [21,22]. First, niacin blocks recruitment of macrophages to atherosclerotic lesions. Second, niacin upregulates macrophage ABCA1 and ABCG1, transporters involved in reverse cholesterol transport. Upregulation of choles

• GLP is an intestinal peptide hormone

  2022-01-14

  

  GLP-1 is an intestinal peptide hormone that is released by the gut following ingestion of food, particularly Epoxomicin and fats. Following its release, GLP-1 stimulates pancreatic β-cells to secrete insulin (Hirasawa et al., 2005, Covington et al., 2006). Originally, GLP-1 acted in a similar manne

• br AUTHOR CONTRIBUTIONS br ACKNOWLEDGMENTS br Introduction C

  2022-01-14

  

  AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS Introduction Chronic neuropathic pain is a common symptom in patients with human immunodeficiency virus (HIV)-1 infection. Glycoprotein 120 (gp120) is an HIV-1 protein that can cause pain behaviors in animal models (Hao, 2013, Nasirinezhad et al., 2015,

• Consistent with these observations impaired transduction of

  2022-01-14

  

  Consistent with these observations, impaired transduction of the glutamate signal by NMDARs (i.e., NMDA receptor hypofunction [NRH]) by parvalbumin-containing GABAergic inhibitory interneurons is implicated in mediating social deficits, a domain of psychopathology responsible for poor functional out

• br Materials and methods br

  2022-01-14

  

  Materials and methods Results and discussion Conclusions In summary, the Au@SiO2 based lateral flow sandwich immunoassay for fast detection of EBN-specific glycoprotein has been firstly established by using nanocomposites as signaling-labels and synthesized EBN-specific amanitin as recognit

• br Regulation of Glu transporters The

  2022-01-14

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino Caspase-3, human recombinant proteinase calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been descr

• Introduction The Hedgehog Hh signaling pathway regulates emb

  2022-01-14

  

  Introduction The Hedgehog (Hh) signaling pathway regulates embryonic organogenesis, tissue patterning, and cell differentiation (Armas-Lopez et al., 2017, Ingham and McMahon, 2013). Aberrant activation of Hh signaling pathway contributes to tumor formation and development of various cancers includi

• To directly address whether pharmacological

  2022-01-14

  

  To directly address whether pharmacological attenuation of physiological GIP provides therapeutic benefits in obese mice, we pursued a selective long-acting antagonist to complement the work we report on GIPR agonism. We report a GIP analog of sufficient aqueous solubility that employs a shortened N

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