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Membrane based integrative treatment processes emerge as pot
2021-11-08
Membrane based integrative treatment processes emerge as potential solution compared to the conventional techniques. Gisi et al. (2009) presented a treatment scheme for tannery wastewater consisting of a biological pre-treatment and then a polymer as coagulant followed by reverse 98059 with a plane
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things br Discussion Regulation of redox homeostasis is crit
2021-11-08
Discussion Regulation of redox homeostasis is critical in the maintenance of normal cell functions, and both glutathione S-transferase and peroxiredoxin enzymes are important contributors to this process. There are numerous reports of aberrant expression patterns of GSTP linked with cancer and wi
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The experiments reported herein were designed to test whethe
2021-11-08
The experiments reported herein were designed to test whether co-expression of MRP and GSTP1-1 offers a level of protection from certain cytotoxic drugs not achieved by the expression of either protein alone. This was accomplished by stable transfection with expression vectors into MCF7/WT cells, w
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br Endogenous and synthetic ligands of GPR There are
2021-11-08
Endogenous and synthetic ligands of GPR55 There are currently limited commercially available synthetic agonists and antagonists that are specific for GPR55. A large number of studies have investigated the pharmacology of GPR55 4, 23, 25, 30, 31, 32, 33, 34, 35, with contradictory findings reporte
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Ironically another series of studies examining the role
2021-11-08
Ironically, another series of studies examining the role of EAATs in CNS injury and disease suggest that under some pathological conditions, the operation of the EAATs is not protective, but actually contributes to the excitotoxic process (Rossi et al., 2000). The transporters do so by serving as th
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br The concept of the axo myelin synapse
2021-11-08
The concept of the axo-myelin ‘synapse’ Axons can release glutamate in a Ca+-dependent and independent manner (reviewed in [13,69]). Glutamate released from axons activates GluRs located in myelin, a feature that gave rise to the idea of the axo-myelin ‘synapse’ by analogy with classical synaptic
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In order to elucidate the reasons of high efficacy of
2021-11-08
In order to elucidate the reasons of high efficacy of , we evaluated the BOC group itself and the linkage between the BOC group and the benzene ring of A-part. Urea moiety (), the replacement of an oxygen (-)-epicatechin of the BOC group to a nitrogen atom, decreased the activity (EC = 0.12 μM), wh
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FFAs concentration response curves for increasing intracellu
2021-11-08
FFAs concentration–response curves for increasing intracellular calcium and receptor phosphorylation showed a difference of ≈1 order of magnitude indicating a relatively large receptor reserve, which is expected for a transfected model, and that high receptor occupancy is necessary to induce recepto
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5,7-Dichlorokynurenic acid receptor Recent evidence indicate
2021-11-08
Recent evidence indicates that prolonged vasoconstriction of conductance and resistance arteries involves VSMCs 5,7-Dichlorokynurenic acid receptor polymerization, through activation of small GTPases [4] and a subsequently transition to a more solid rheology [5]. Actin polymerization occurs in two
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br Introduction In addition to
2021-11-08
Introduction In addition to glucose, which is the foremost stimulator of insulin secretion in beta-cells, other nutrients such as free fatty acids (also called non-esterified fatty acids, NEFA) contribute to glucose-stimulated insulin secretion (GSIS). Glucose triggers the processes leading to in
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INK 128 br STAR Methods br Acknowledgments We
2021-11-08
STAR★Methods Acknowledgments We would like to thank V. Gladyshev (Harvard), H. Kornblum (UCLA), L. Greene (Columbia), and J. Baraban (Johns Hopkins) for constructive comments to the project and manuscript. We thank L. Gross and A. Kumar for assistance with editing. We thank L.M. Gerber and Z.
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Importantly both genetic deletion and pharmacological
2021-11-08
Importantly, both genetic deletion and pharmacological inhibition of FAAH also reduced NTG-induced neuronal hyperactivity in the trigeminal nucleus, which receives sensory input from craniofacial deep tissues. NTG is known to evoke the robust neuronal activation, as evidenced by the induction of the
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Since stroke and cerebrovascular diseases were considered se
2021-11-08
Since stroke and cerebrovascular diseases were considered serious AEs following vaccination, we performed manual chart review to confirm the diagnosis and symptom onset date for all stroke and cerebrovascular disease cases identified by ICD-9 codes. Chart review of 131 presumptive cases confirmed 82
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br Materials and methods br Results br Discussion GSK overex
2021-11-06
Materials and methods Results Discussion GSK-3 overexpression diminishes neurogenesis (Fuster-Matanzo et al., 2013, Kondratiuk et al., 2013, Sirerol-Piquer et al., 2011), while the inhibition of GSK-3 with lithium or valproate enhances neurogenesis, as measured by cell proliferation, the nu
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br Materials and methods br Results
2021-11-06
Materials and methods Results Discussion In this report, we have analyzed the function of an orphan GPCR, and GPR84, using genetically-deficient mice. The expression of GPR84 in the T and ticarcillin in the spleen prompted us to examine the functional responses of these cells under in vitr
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