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ANT located in the IMM mediates the exchange of ATP
2022-06-02
ANT, located in the IMM, mediates the exchange of ATP/ADP between the mitochondrial matrix and the intermembrane space (IMS) (Brand et al., 2005; Palmieri and Pierri, 2010). Of the 4 known isoforms, ANT1 is the dominant isoform in the heart (Palmieri and Pierri, 2010). Under physiological conditions
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Following nerve injury Shh expression is upregulated in neur
2022-06-02
Following nerve injury, Shh expression is upregulated in neuronal cell bodies of the facial and sciatic nerves. Additionally, Shh appears to be required for normal regeneration in vivo, and promotes motor neuron survival in vitro (Martinez et al., 2015; Akazawa and Kohsaka, 2007). Based on these obs
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Overall more males were HCV mono and co infected
2022-06-02
Overall, more males were HCV mono- and co-infected, though there was no significant age difference among groups and between men and women (all p>0.05). Almost all patients included in this study were over 40 years, in line with the period in which no HCV screening was performed in Brazilian blood b
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It has been indicated that chemicals induced mammalian cell
2022-06-02
It has been indicated that chemicals-induced mammalian cell death is mediated by GSK-3 activation (by downregulated of GSK-3 phosphorylation) leading to apoptosis (Huang et al., 2014, Li et al., 2014, Tanabe et al., 2011, Yun et al., 2009). In contrast, accumulating evidences have reported that the
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A subsequent modeling study by a different group was
2022-06-02
A subsequent modeling study by a different group was based on the bovine rhodopsin homology model using the 1L9H construct [38]. However, the site-directed mutagenesis data and docking suggested that the niacin-binding pocket is different to that described in the aforementioned report, but similar t
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Research of Kojima et al DeJarnette et al and Saldarriaga
2022-06-02
Research of Kojima et al. (2000); DeJarnette et al. (2001), and Saldarriaga et al. (2007) inferred that synchronization of NFWE is related to ovulation response after GnRH-1. In the research of Saldarriaga et al. (2007) with Bos indicus-influenced beef cows, ovulation rate was 40% and estrous synchr
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As preclinical toxicity and efficacy both appear
2022-06-02
As preclinical toxicity and efficacy both appear to be associated with GlyT1 inhibition, it remains to be determined whether on-target toxicity can be separated from efficacy. The present study evaluated a series of GlyT1 inhibitors for target potency, mode of inhibition, residence time, activity in
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br Acknowledgements br Introduction Aminoacyl tRNA
2022-06-01
Acknowledgements Introduction Aminoacyl-tRNA synthetases catalyze the formation of an ester bond between an amino Desfuroylceftiofur and the 3′ end of a tRNA in a two-step reaction. First, the amino acid is activated and an enzyme-bound adenylate intermediate is formed. Then, the amino acid i
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br Acknowledgments br Introduction Postmenopausal osteoporos
2022-06-01
Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by tamoxifen citrate deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately
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br Hedgehog HH signaling plays
2022-06-01
Hedgehog (HH) signaling plays an important role both during embryonic development and adult life. It is involved in the regulation of cell differentiation, cell proliferation and tissue polarity, as well as in the maintenance of stem cells, tissue repair, and regeneration (, ). Three ligands, Indi
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Moreover the ubiquitous expression of the OTR
2022-06-01
Moreover, the ubiquitous Cap Firefly Luciferase mRNA of the OTR and GHSR was also observed in hippocampal and hypothalamic primary culture, indicating that this expression pattern is likely due to basal activity of these receptors. GPCR trafficking under control conditions has been linked to biased
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br Conclusions br Acknowledgement Work in the
2022-06-01
Conclusions Acknowledgement Work in the authors’ labs was funded by Natural Sciences and Engineering Research Council of Canada (OGP0194652 and OGP0041653) and Diabète Québec. Introduction Fifty years ago, Sydney Brenner proposed Caenorhabditis elegans as a useful model for the study of an
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br STAR Methods br Introduction Secretase is a membrane
2022-06-01
STAR★Methods Introduction γ-Secretase is a membrane-embedded proteolytic complex belonging to a diverse family of intramembrane-cleaving proteases and is composed of four integral membrane proteins: presenilin (PS), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin enhancer
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Based on the collective experience to
2022-06-01
Based on the collective experience to date, it is likely that a much more comprehensive assessment of GSI selectivity for inhibition of multiple substrates, as well as biomarkers to track inhibition of non-APP substrates in vivo will be needed to support future efforts to develop substrate selective
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In summary this study demonstrated the
2022-06-01
In summary, this study demonstrated the cDNA cloning and characterization of the galanin type II receptor (GalR2) and a novel GalR2-like receptor (GalR2-L) in chickens, in which these two receptors are possibly originated from a gene Benztropine mesylate sale event that occurred in the early verteb
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