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Type diabetes mellitus is characterised by two major feature
2022-06-24
Type 2 diabetes mellitus is characterised by two major features: peripheral insulin resistance and impaired insulin secretion from pancreatic beta TNF-alpha, recombinant human protein [1]. The condition occurs when the pancreatic beta cells are unable to compensate for increased insulin demand due t
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br Conclusions Temporally controlled disruption of
2022-06-24
Conclusions Temporally-controlled disruption of Gcgr reveals a lack meaningful contribution to the improvement of glycemic control in insulinopenic conditions attributable to the intrinsic loss of GCGR signaling. On the other hand, these data highlight the importance of compensatory systems, incl
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Regulation of pancreatic and cell mass has been
2022-06-24
Regulation of pancreatic α and β cell mass has been extensively studied and hotly debated, due to potential therapeutic implications. Early claims of Angptl8 as “betatrophin” and Angptl4 as a regulator of glucagon secretion and α cell proliferation (Yi et al., 2013, Ben-Zvi et al., 2015) have not st
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br Therapeutic approaches exploiting Cx function Due to
2022-06-24
Therapeutic approaches exploiting Cx43 function Due to their potential role in cancer metastasis, attempts have been made to alter connexin function to inhibit cancer growth. Therapeutic approaches include Cx43 peptide mimetics, Cx43 inhibitors, chemical agents capable of enhancing Cx43 function,
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It has also been demonstrated that PS
2022-06-24
It has also been demonstrated that PS1 is ubiquitinated by Caenorhabditis elegans SEL-10 [52], Fbw7 the mammalian homologue of SEL-10 [38], and more recently by tumour necrosis factor Mirtazapine associated factor 6 (TRAF6), which facilitates Lysine-63 (K63)-linked polyubiquitination of PS1 [50], [
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ion channels Cys loop GABA receptors are well studied
2022-06-24
Cys-loop GABA receptors are well-studied targets for insecticides and also play an important role in nematode biology. These receptors are also targets for the anthelmintic piperizine (Accardi et al., 2012). The nematode GABA receptor most studied is the UNC-49 receptor which plays a role in muscle
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FBPase deficiency is a very rare inborn error of
2022-06-24
FBPase deficiency is a very rare inborn error of fructose YK-4-279 of autosomal recessive inheritance. This disorder usually occurs in the first year of life through ketotic hypoglycemia and lactic acidosis triggered by catabolic episodes such as prolonged fasting or febrile infections (Steinmann e
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Trifluoromethyl ketones and fluorophosphates were the
2022-06-24
Trifluoromethyl ketones and fluorophosphates were the first generation FAAH inhibitors identified. They showed good in vitro FAAH inhibition potency, but most of them exhibited poor selectivity for FAAH over other serine hydrolases (such as the triacylglycerol hydrolase and the membrane-associated h
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The EZH overexpression group exhibited
2022-06-24
The EZH2 overexpression group exhibited upregulated CEP55 expression but downregulated methylation, suggesting that changes in EZH2 expression in lung adenocarcinoma result in differences of CEP55 methylation and expression. Moreover, according to TCGA database and GSE27262 chip data, CEP55 expressi
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Oxaprozin br Mechanisms of HDAC inhibition dependent
2022-06-23
Mechanisms of HDAC inhibition-dependent cardioprotection Multiple preclinical studies have demonstrated potent cardioprotective benefits of HDAC inhibition in murine models of myocardial stress, including I/R [19,25,29,30]. TSA reduces myocardial infarct size by up to 50% [19,25]. In addition, tr
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Human immunodeficiency virus type HIV is responsible for
2022-06-23
Human immunodeficiency virus type 1 (HIV-1) is responsible for the Ginkgolic Acid C15:1 australia pandemic; notification is compulsory in Brazilian blood banks since 1988. From 1980 to 2016, the Brazilian MH reported 882,810 HIV/AIDS cases, with 52.3% in the southeast region. HIV/HCV co-infection
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br Results br Discussion To
2022-06-23
Results Discussion To further evaluate the extent of H3T3A and H3T3D roles in the segregation of sister chromatids enriched with different populations of H3 during mitosis (Figure 1B, step two), we modeled all possible segregation patterns in male GSCs and compared these estimates to our exper
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br Methods br Results br Discussion Peptide therapeutics rep
2022-06-23
Methods Results Discussion Peptide therapeutics represents a unique class of biopharmaceuticals that continues to evolve in drug discovery and development. We and others have been particularly interested in bioengineering innovative pGC-A and/or pGC-B peptide activators. This has been succe
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We observed that the Toc G domain recognizes the N
2022-06-23
We observed that the Toc159G domain recognizes the N-terminal portion of the transit peptide of pSSU with a dissociation constant of 70 μM (Fig. 2; Table 1), while a tenfold higher KD was obtained for the phosphorylated C-terminal region. In turn, the homodimer of Toc34G recognizes the phosphorylate
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GSTP catalyzed reduction of Prdx enhances
2022-06-23
GSTP1-1 catalyzed reduction of Prdx6 enhances its peroxidase activity. Using standard NADPH/GR/GSH-coupled assays we used cell lysates from the transiently transfected AG-126 to measure the influence of GSTP1 allelic variation on peroxidase activity. Specificity for detection of Prdx6 activity was
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