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In conclusion phenolic hydroxyl was
2023-01-30
In conclusion, phenolic hydroxyl was introduced not only to C3 side chain but also to C6 or C7 position of the quinoxalinone core, resulting in a new group of ARIs candidates exhibiting antioxidant activity. Biological activity tests suggested that compounds were not only sufficient to inhibit ALR2
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The most widely recognized effects of adenosine are
2023-01-30
The most widely recognized effects of adenosine are operated through inhibiting A1R, one of the most abundant G protein-coupled receptors in eukaryotic initiation factor tissue [53]. A1R are located presynaptically, postsynaptically and nonsynaptically [54]. Effect of adenosine in neuronal circuits
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br Discussion Mycobacterium tuberculosis infection is a
2023-01-30
Discussion Mycobacterium tuberculosis infection is a main threat to mankind, with one third of the world population being infected. [9] Over nine million new cases of tuberculosis and two million deaths from this disease occur yearly worldwide. [10] The rising incidence of tuberculosis over the l
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The lanthanide series of chemical elements comprises the fif
2023-01-30
The lanthanide series of chemical elements comprises the fifteen metallic chemical elements with atomic numbers 57 through 71, from lanthanum to lutetium. Though originally described as ‘‘rare earths’’ because of their natural occurrence as metal oxides, they are not particularly rare. The lanthanid
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Prostate cancer is the second leading cause of cancer
2023-01-30
Prostate cancer is the second leading cause of cancer-related death in men in the United States [25]. Similar to pancreatic cancer, prostate cancer has few diagnostic options available, particularly to differentiate indolent from aggressive disease. Axl is also overexpressed in ∼50% of prostate canc
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In addition to the data
2023-01-30
In addition to the data provided by the Ki16425 treatment in the K/BxN arthritis model, new findings from the study of two new LPA receptor antagonists confirm the involvement of the LPA pathway in the pathogenesis of experimental arthritis. In the study by Miyabe et al., the authors reported the tr
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br Funding br Ethics br Conflict of interest
2023-01-30
Funding Ethics Conflict of interest Acknowledgements Introduction Hepatic fibrosis occurs in response to different etiologies of chronic liver injury, which is mainly accompanied by pathological pfk of excessive extracellular matrix (ECM) of the liver, as the common reaction of multip
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Of note core autophagy factors also play
2023-01-30
Of note, core autophagy factors also play an important role during the infection of host cells by another type of picornavirus, namely, echovirus 7. ATG16L1 was found necessary for entry/internalization into Caco-2 polarized epithelial cells because the virus accumulated on the surface of ATG16L1-de
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The LO has so far only been found in
2023-01-30
The 15-LO-1 has so far only been found in humans and rabbit reticulocytes [3], [20] and the rabbit 15-LO-1 protein demonstrate 81% identity to the human 15-LO-1. However, rabbit monocytes express an enzyme with mainly 12-LO activity [20], [21]. The high degree of sequence conservation between these
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br Mechanisms of GPCR internalization Like for other types o
2023-01-30
Mechanisms of GPCR internalization Like for other types of receptors, prolonged agonist stimulation often leads to GPCR internalization, which can occur via different pathways ∗[2], [20], [21], [22], [23]. Of these pathways, clathrin-mediated icrt synthesis (CME) is the best characterized and ar
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br Experimental Procedures Additional information can be fou
2023-01-30
Experimental Procedures Additional information can be found in Supplemental Experimental Procedures. Author Contributions Acknowledgments We thank all members of Lab of Health Chemistry for helpful discussions. This work was supported by Grant-in-Aid for Scientific Research (KAKENHI) from
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br Experimental and simulation section br Acknowledgments Fi
2023-01-30
Experimental and simulation section Acknowledgments Financial support for this work was provided by the National Natural Science Foundation of China (No. 81101688). We would like to thank NC State University High Performance Computing Center for providing us computing resources, and Dr. Lihui
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CB-839 In summary this report demonstrates
2023-01-30
In summary, this report demonstrates another successful application of gene editing in iPSCs. Despite the lack of efficient metabolic functional repair after transplantation, the application of gene correction into HLCs might still be a realistic goal for ex vivo gene therapy of liver diseases with
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Arginases from several species and tissues have been found t
2023-01-30
Arginases from several species and tissues have been found to be inhibited by amino acids [51]. In the present study, monocarboxyilic amino acids with five or more carbon atoms such as ornithine, lysine, valine, leucine and isoleucine inhibited CL-ARG. The results revealed that as the amino Telatini
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Plasma apelin levels predict the major cardiovascular event
2023-01-30
Plasma apelin levels predict the major cardiovascular event after percutaneous coronary intervention in patients with ST elevation myocardial infarction (STEMI), and adverse events are higher in patients with lower plasma apelin levels [75]. Apelin and its receptor are markedly upregulated in the he
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