• One of the major challenges

  2018-11-08

  

  One of the major challenges in scaling up of hESC cultures is the effects of the mechanical stimulation generated by the hydrodynamic shear forces which is an inherent property of agitated cultures (Earls et al., 2013). Previous studies done with mouse embryonic stem cells have shown that fluid shea

• cannabinoid receptor br Myocardial regeneration after alloge

  2018-11-08

  

  Myocardial regeneration after allogeneic stem cell therapy Moreover, as outlined above, a consensus is gaining ground that most of the favourable effects of cell transplantation protocols used until now exert their beneficial effect by a paracrine mechanism of the transplanted cannabinoid recepto

• Introduction The mechanisms by which pluripotency regulators

  2018-11-08

  

  Introduction The mechanisms by which pluripotency regulators dictate self-renewal versus differentiation are only recently being studied (Wagner et al., 2010; Niwa et al., 2009). In addition, various approaches are being developed to examine such processes (Wang et al, 2013). The transcriptional re

• br Materials and methods br

  2018-11-08

  

  Materials and methods Acknowledgements Mef2c-AHF-Cre mice were generously provided by Dr. Brian L. Black. We thank Mamen Martín and Sandra Rodríguez (Molecular Cytogenetics Unit, CNIO) for technical advice; and the Imaging Core Facility for the confocal analysis (CIMA, University of Navarra).

• Also critical to the success of

  2018-11-08

  

  Also critical to the success of hard tissue engineering strategies is the selection and use of an appropriate growth factor regimen. Although several growth factors are reported to play an important role in the process of matrix mineralisation, IGF-1 is the most abundant growth factor in bone matrix

• No effective therapies are available for motor neuron diseas

  2018-11-08

  

  No effective therapies are available for motor neuron diseases, including SMARD1. Neural stem cell (NSC) transplantation represents a possible therapeutic strategy for ameliorating the neurological phenotype by multiple mechanisms, including neuroprotection and cell replacement of different CNS ci-1

• A recent study indicated that

  2018-11-08

  

  A recent study indicated that XIST expression can be lost upon prolonged passaging of female hiPSCs, referred to as “erosion of XCI” (Mekhoubad et al., 2012). This epigenetic erosion was found to be irreversible and correlated with a loss of differentiation characteristics and is very relevant for d

• The creation and maintenance of

  2018-11-08

  

  The creation and maintenance of subcutaneous patient-derived xenografts (PDX) from fresh or cryopreserved ACC tissue (Moskaluk et al., 2011) provided a renewable source of ACC casr for validation of our CSC hypothesis. As we previously demonstrated, these PDX models reproduced ACC morphology and ma

• Multi electrode array approaches have been proposed as a too

  2018-11-08

  

  Multi-electrode array approaches have been proposed as a tool for detecting functional changes in electrically excitable cells, including neurons, exposed to drugs or toxins and allow use in high throughput studies (McConnell et al., 2012). Although there are a number of electrophysiological measure

• Collectively these results indicate that both CXCR and CXCR

  2018-11-08

  

  Collectively, these results indicate that both CXCR4 and CXCR7 are necessary for proper differentiation and function of hiPSC-CMs and hECTs, but they might act by separate mechanisms. There have been multiple reports suggesting differential signaling and activity of SDF-1/CXCR4 and SDF-1/CXCR7 pathw

• Genome wide association studies GWASs represent another unbi

  2018-11-08

  

  Genome-wide association studies (GWASs) represent another unbiased approach that has proven particularly successful in humans for gene discovery of numerous disease phenotypes (Hindorff et al., 2015). Encouraged by this success, GWASs also have been proposed in mice using a recently developed panel

• Our study showed that neurite length and

  2018-11-08

  

  Our study showed that neurite length and the ratio of apoptotic luliconazole in FALS- and FUSH517D/H517D iPSC-derived neurons were the same as in control motor neurons. With several stresses especially in glutamate treatment, however, FALS- and FUSH517D/H517D HB9-positive motor neurons exhibited sh

• br Results br Discussion Similarly to unconditioned adult

  2018-11-08

  

  Results Discussion Similarly to unconditioned adult recipients, transplantation of allogeneic HSC into non-ablated fetal hosts faces serious challenges. Immunologic barriers posed by the mother\'s immune system (Merianos et al., 2009; Nijagal et al., 2011) and by the emerging innate and adapti

• br Experimental Procedures br Author Contributions br Acknow

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments We thank Ms. Y. Ogata for technical assistance. Financial support for this research was provided by the Uehara Memorial Foundation, Takeda Science Foundation, the Naito Foundation, the Ministry of Education, Culture, Sports, Scien

• In the present study we carried out an expression

  2018-11-07

  

  In the present study, we carried out an expression profile analysis of GPCRs in mESCs and mESC-derived ECs, and observed inordinately high expression of the orphan receptor GPR56 (Huang et al., 2008) and, importantly, of PAR1 in the ECs generated from ESCs. We focused on PAR1 not only as it is highl

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