• br cDNA cloning gene structure and chromosomal localization

  2023-10-27

  

  cDNA cloning, gene structure and chromosomal localization The cDNA for the leukocyte-type 12S-lipoxygenase was first cloned from porcine leukocytes [9], and later from mouse [10], [11], rat [12], [13], bovine [14] and rabbit [15] sources. The cDNA for the platelet-type 12S-lipoxygenase cDNA has b

• br Preliminary remarks Expression of the transcription

  2023-10-27

  

  Preliminary remarks Expression of the transcription factor aryl hydrocarbon receptor (AHR) and the AHR-repressor (AHRR) are both strikingly high in the Rottlerin of barrier organs skin and gut [1,2]. It is generally assumed that this reflects their role in linking environmental factors to an adap

• br Introduction Psychostimulant abuse and addiction remain a

  2023-10-27

  

  Introduction Psychostimulant abuse and addiction remain a societal problem in the United States. The latest statistics from the National Survey on Drug Use and Health indicate that slightly less than one million people over the age of 12 report having a cocaine use disorder (NSDUH, 2016). Additio

• Adiponectin belongs to the CTRP C

  2023-10-27

  

  Adiponectin belongs to the CTRP (C1q/TNF-related protein) superfamily. Except for adiponectin, 15 additional members have been identified (CTRP1-15) (Schaffler and Buechler, 2012). Of all the CTRPs, CTRP9 has the highest identity to adiponectin in globular domain (Wong et al., 2009). The structure o

• It is worth pointing out that phenotypes of in vivo

  2023-10-27

  

  It is worth pointing out that phenotypes of in vivo HSP90β inhibition were not identical to those observed in rapsyn mutant mice (Gautam et al., 1995). Postsynaptically, junctional AChR clusters appeared fragmented, in addition to expected reduction in AChR intensity, in muscles injected with 17-AAG

• Previously we reported that EL Kras mice fed diets

  2023-10-27

  

  Previously, we reported that EL-Kras mice-fed diets rich in omega-6 FAs demonstrated increased pancreatic mast cell infiltration [16]. Significantly, increased infiltration of mast cells into the tumor microenvironment correlates with a poor prognosis [15]. Soucek et al.[25] demonstrated that mast c

• Cyt 387 Acknowledgments br P c is expressed in several stero

  2023-10-27

  

  Acknowledgments P450c17 is expressed in several steroidogenic tissues, including the adrenal cortex, the ovary, and the testes (). Thus, 17α-hydroxylase/17,20-lyase is a key enzyme required for the production of both cortisol and sex steroids. This enzyme defect blocks the synthesis of cortisol,

• br Conclusion br List of abbreviations br Acknowledgment

  2023-10-27

  

  Conclusion List of abbreviations Acknowledgment The studies performed by our laboratory and presented in this review were supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, (KAKENHI 17590618 [to H.I.] and KAKENHI 22249017 [to Y.Y.]), and the Japanese S

• Pompe disease is accompanied by the deficiency

  2023-10-27

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the yohimbine hydrochloride unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation res

• Previously using a P lacZ reporter gene system

  2023-10-27

  

  Previously, using a P-lacZ reporter gene system, it has been shown that the β-galactosidase activity was 9-fold higher in the stationary phase T0070907 when compared with those of the exponential phase [15]. Furthermore, inositol supplementation did not have a major effect on the expression of β-gal

• It has also been reported that defects in

  2023-10-27

  

  It has also been reported that defects in ATM or ATR signalling are synthetically lethal with PARP inhibition (Turner et al., 2008, Peasland et al., 2011, Yap et al., 2011, Michels et al., 2014), suggesting that combined inhibition of PARP and ATM or ATR may be an effective therapeutic strategy. In

• APJ is mainly coupled to PTX sensitive

  2023-10-26

  

  APJ is mainly coupled to PTX-sensitive Gi/o proteins [33], and thus, it is associated with the inhibition of adenylyl cyclase and the activations of PI3K/Akt signaling and MAPKs signaling pathways [23], [54], [55], [56]. In a previous study, apelin stimulations of the PI3K/Akt and/or the MAPK pathwa

• We provide here direct evidences that AT

  2023-10-26

  

  We provide here direct evidences that AT1 receptors are active in ADSCs since Ang II induces intracellular Ca mobilization in these cells. Data obtained during the observation of Ca influxes led us to the search for the ADSCs subpopulation constantly expressing AT1 receptor. ADSCs are necessary for

• Electron paramagnetic resonance studies of mixtures of A

  2023-10-26

  

  Electron paramagnetic resonance studies of mixtures of Aβ1–40 and Aβ1–42 suggest that interlaced fibrils might also form [40] where Aβ1–40 and Aβ1–42 is found within the same fibril. Considering the Aβ fold rather than the sequence, these observations imply two mechanisms that might lower the total

• Besides its multiple peripheral effects adiponectin may amel

  2023-10-26

  

  Besides its multiple peripheral effects adiponectin may ameliorate insulin resistance by acting in the brain, and intracerebroventricular administration of adiponectin in rodents decreases body weight by stimulating energy expenditure [13]. Adiponectin most likely crosses the blood-CSF-barrier (BCB)

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